Plectranthus barbatus -Coleus Forskohlii

Scientific Name : Plectranthus barbatus
Common Name : Coleus Forskohlii
Source : Root
Composition : 10% 20%,40 % Forskolin
Applications : Sports nutrition ,Weight management

The persistence of traditional medicine depends on the diversity and knowledge on medicinal properties of the plant. India is considered as a hot spot region for the plant diversity and about one-fifth of the Indian plants are found to have medicinal properties.1 Coleus forskohlii Briq. (Syn. Plectranthus barbatus Andr.) is a common indigenous medicinal plant belonging to Lamiaceae family.2 Plant derivatives play a vital role in the world market for their mostly for their pharmaceutical properties. Phytochemicals are used in the medicines such as vinblastine and vincristine (Catharanthus roseus), taxol (Taxus brevifolia), camptothecin (Camptotheca acuminate), and Forskolin (C. forskohlii) an Indian Ayurvedic drug.3

In modern medicine, C. forskohlii gained importance after the emergence of the therapeutic properties of the Forskolin (FSK, 3) (7-β-acetoxy-8, 13-epoxy-1α, 6 β, 9α-trihydroxy-labd-14-ene-11-one). It is the active ingredient present in C. forskohlii which played a major role in stimulating cyclic adenosine monophosphate (cAMP) and other biological activities4 and further exhibits some anti-bacterial activity.5This monophosphate acts as the second messenger for intracellular signal transduction and also regulates the number of enzymes, hormones, and other biological activities. Therefore, any impairment occurred in this pathway leads to the diseased condition. For instance, asthma and allergic conditions is characterized by decreased cAMP level in bronchial smooth muscles. In general, cAMP regulates the body’s thermogenic response to food, increases the body’s basal metabolic rate, and further increases the utilization of body fat.6

 References:

  1. Schippmann U, Leaman D, Cunningham A. Biodiversity and Ecosystem Approach in Agriculture, Forestry and Fisheries. Rome: FAO; 2002. Impact of cultivation and gathering of medicinal plants on biodiversity: Global trends and issues; pp. 1–121.
  2. Bone K. The Ultimate Herbal Compendium. Queensland: Phytotherapy Press; 2007
  3. Vanisree M, Lee C, Lo S, Satish M, Lin C, Tsay HS. Studies on the production of some important secondary metabolites from medicinal plants by plant tissue cultures. Bot Bull Acad Sin. 2004;45:1–22.
  4. Caprioli J, Sears M, Bausher L, Gregory D, Mead A. Forskolin lowers intraocular pressure by reducing aqueous inflow. Invest Ophthalmol Vis Sci. 1984;25:268–77.
  5.  http://www.linkinghub.elsevier.com/retrieve/pii/S0031942296004670
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471649/

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Technical Specifications

Composition: 10% 20%, 40% Forskolin

Description / Appearance : Brown to light brown colored Powder
Odour : Characteristic
Identification : By HPLC
Loss on Drying : NMT 5% w/ww
Residue on ignition : NMT 5% w/w
Forskholin content (By HPLC) : NLT 40.0% w/w on dry basis

Total Heavy Metals

Lead : NMT 3.0 ppm
Arsenic : NMT 1.0 ppm
Mercury : NMT 0.1 ppm
Cadmium : NMT 0.3 pm

Microbiology Tests :

a) Total Aerobic Count : NMT 5000 cfu/gm
b) Yeast & Mould : NMT 100 cfu/gm
c) Salmonella : Absent in 1gram
d) Escherichia coli : Absent in 1gram
e) Staphylococcus aureus : Absent in 1 gram

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